Cryptocurrencies came under selling pressure during Wednesday's trading, as investors' appetite for high-risk assets waned after US President Donald Trump's comments dashed hopes for a near-resumption of talks with Iran, bringing geopolitical concerns back to the forefront of global markets.

The decline followed Trump's confirmation that the United States was not interested in holding talks with Tehran at present, despite his assertion that Iran was eager to meet. Iranian authorities quickly denied these statements, emphasizing that they had not requested any negotiations with Washington. These developments fueled investor concerns about a potential escalation of military tensions in the region, prompting them to reduce their exposure to more volatile assets.

This comes at a time when markets are increasingly sensitive to any developments related to the crisis in the Middle East, given its potential impact on energy prices, global inflation, and the course of monetary policy – factors that directly affect the performance of cryptocurrencies, which typically decline as risk aversion levels rise.

In trading, Bitcoin, the largest cryptocurrency by market capitalization, fell 1% to below $66,000, reaching $65,762. Ethereum also declined by 0.59% to $1,911.49, while Ripple dropped 1.57% to $1.1303.

Despite this decline, investors continue to monitor the flows of cryptocurrency exchange-traded funds (ETFs), along with updates on US monetary policy, as these are among the most prominent factors that may determine the direction of the market in the coming period, in light of the continued volatility resulting from geopolitical developments.